Endocrine Abstracts

Bone is the major sink and store for calcium and it fulfils essential roles in the maintenance of extracellular free ionised calcium concentration ([Ca2+e)within its homeostatic range (1.1 to 1.3mM). In response to acute hypercalcaemia or hypocalcaemia, Ca2+ is rapidly transported into or out of bone. Bone turnover (and therefore bone Ca2+ turnover) achieves the long term correction of the [Ca2+e] by the metabolic actions of osteoblasts (i.e., bone-forming cells) and osteoclas...